Will anti-depressants show up in drug screen?

No.

Antidepressants will not show up on standard drug tests. However some commonly used drug tests will detect tricyclic antidepressants (TCA's), an older class of antidepressants.

Since antidepressants (including TCA's) are not addictive or controlled substances there is rarely a need to test for them. It is technically possible to test for any drug but employer, military, home, and hospital drug tests will not test for them (although some home drug tests and hospital tests will find TCA's).

A class of drugs known as benzodiazepines (Valium, Xanax, Ativan, Klonopin/Rivotril, Serax, Restoril) are often incorrectly described as antidepressants. These drugs are often tested for due to their potential for abuse, however most drug tests only test for PCP, cocaine, amphetamines (including meth and ecstasy), opiates (codeine, morphine, and heroin), and THC (marijuana). Benzodiazepines, barbiturates, and oxycodone are the most common tests added to the basic 5-panel test.

If any drug were to show up on a drug test you would not have a problem if you can provide a valid prescription.