What enzyme class splits a chemical bond in the absence of water?

The enzyme class that splits a chemical bond in the absence of water is known as lyases. Lyases catalyze the breaking of bonds by means other than hydrolysis or oxidation, often forming a double bond or a ring structure in the process. They play crucial roles in various metabolic pathways, such as the conversion of glucose to pyruvate in glycolysis. Examples of lyases include decarboxylases and deaminases.