How was the Cheyenne tribe affected by Manifest Destiny?

The Cheyenne tribe was significantly affected by Manifest Destiny as westward expansion led to the encroachment on their ancestral lands. This resulted in violent conflicts, such as the Sand Creek Massacre of 1864, where many Cheyenne were killed by U.S. troops. Additionally, the U.S. government's policies aimed at assimilation and relocation further disrupted their traditional way of life, leading to loss of culture and resources. Overall, Manifest Destiny contributed to the marginalization and suffering of the Cheyenne people.