Why does Cymbalta stop working?

Cymbalta (duloxetine) may stop working for several reasons, including the development of tolerance, changes in the underlying condition being treated, or alterations in the body's metabolism and neurotransmitter levels. Stressors or lifestyle changes can also impact its effectiveness. Additionally, interactions with other medications or health issues might reduce its efficacy. If Cymbalta is no longer effective, it's important to consult a healthcare provider for reassessment and potential adjustments to the treatment plan.