What are the ethical problems faced by test tube babies?

There is a plethora of medical and philosophical ethical questions behind "growing" humans experimentally. The first comes the ethical question of meddling with nature and genetics. These herald warnings in literature such as Mary Shelly's Frankenstein against playing with science and nature. Other considerations are on the social and economic implications of the affluent able to custom design humans, while others do not have the financial means to do so. It also becomes an equality question if humans with super traits are engineered and designed.