To deactivate the seatbelt chime in a Lexus LS460, first, ensure the vehicle is in the "On" position without starting the engine. Then, buckle and unbuckle the driver's seatbelt three times, ending with the seatbelt unbuckled. After that, turn the ignition off and then back on. This should disable the chime, but consult the owner's manual for specific instructions or variations based on model year.
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