When should you take Prednisone prescribed qid?

12-6-12-6 is one option, but prednisone should be taken with food, and the prescriber normally doesn't intend for you to interrupt your sleep to take it. For that reason, prednisone qid is most often taken with breakfast, lunch, dinner, and snack near bedtime. Talk to your prescriber or pharmacist for advice specific to your situation.