What are the two antigens that are responsible for human blood typing?

The two primary antigens responsible for human blood typing are A and B antigens, which are found on the surface of red blood cells. These antigens determine an individual's blood type in the ABO blood group system, which includes types A, B, AB, and O. The presence or absence of these antigens, along with the Rh factor (positive or negative), defines a person's complete blood type.