What presidents have lost children while in office?

Six men-John Adams, Thomas Jefferson, Franklin Pierce, Abraham Lincoln, Calvin Coolidge, and John F. Kennedy-lost children while serving as (or about to serve as) chief executive. Adams's grown son Charles died in 1800, shortly after the president lost his reelection bid. Jefferson's grown daughter Mary died in 1804. Pierce lost all three of his sons at an early age. Eleven-year-old Benny, his only surviving child, was killed in a train accident in January 1853, two months before Pierce's inauguration. Abraham Lincoln lost his son William ("Willie") in 1862 in the middle of the Civil War. His death devastated first lady Mary Lincoln's psyche and furthered the president's empathy toward the nation's tremendous suffering. Calvin Coolidge Jr. died after contracting blood poisoning from an infected blister in 1924. John F. Kennedy lost his son Patrick two days after he was born on August 7, 1963.