Can you spend uncirculated coins

There's nothing stopping you from spending uncirculated coins, but they are typically worth more than their face value. That is, your uncirculated nickel may be worth 10 cents. And as soon as you spend them as regular change the coin loses its uncirculated status. You'd be better off selling uncirculated coins to a collector or a dealer. Most will be happy to buy your uncirculated coins for more money than you would get by spending them as change.