In some types of colon cancer stem cells have a mutation in the APC gene. What happens if the APC gene is mutated?

When the APC gene is mutated, it disrupts the normal regulation of cell growth and division in the colon. APC normally acts as a tumor suppressor, helping to control the Wnt signaling pathway, which is crucial for maintaining proper cell function. A mutation can lead to uncontrolled cell proliferation, contributing to the development of benign polyps and, ultimately, colorectal cancer. This mutation is a key early event in the progression of certain types of colon cancer.