Help patient refuse to take medication?

My mother had brain surgery over 3 years ago and she has been home, in and out of rehabilitation-nursing home facilities. She hasn' gotten any better since she has been home. She refuses to take her medication. She is suppose to take medication for the seizure, which is seizure that she stares in space and her short term memory gets erased. She also should be taken medication for her High blood pressure but she doesn't take it. She doesn't walk anymore because she complains of her legs but she get therapy but doesn't want anyone to touch her. She stop going to the bathroom. she was diagnosed with being a depressed recently and the doctor prescribed medication but she refuses that also. She has a home attendant who changes her pampers but my mother is only 64, but she is fading away. I don't know what to do?