Typhus primarily causes systemic illness characterized by high fever, severe headache, and rash, resulting from the infection of the endothelial cells lining blood vessels. This can lead to complications such as vasculitis, which may result in organ damage due to impaired blood flow. In severe cases, typhus can lead to shock, respiratory failure, and even death if left untreated. The specific symptoms and severity can vary depending on the type of typhus, such as epidemic or endemic typhus.
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