Which layer of the epidermis will be supplied with the highest levels of oxygen from the blood?

The layer of the epidermis that receives the highest levels of oxygen from the blood is the stratum basale, also known as the basal layer. This is the deepest layer of the epidermis, where cells are actively dividing and are closest to the underlying dermis, which contains blood vessels. Oxygen and nutrients diffuse from the dermal capillaries into the stratum basale, supporting cellular metabolism and growth. As you move up through the layers of the epidermis, the supply of oxygen decreases, as these upper layers are avascular and rely on diffusion.