Is it safe to take 325 by 5 norcos with Tylenol 3?

Taking 325 mg of acetaminophen (Tylenol) with Norco, which contains acetaminophen and hydrocodone, can lead to an overdose of acetaminophen if the total intake exceeds the recommended limit of 4,000 mg per day. It's essential to consider the total amount of acetaminophen from both medications to avoid toxicity. Always consult a healthcare professional before combining medications to ensure safety and appropriate dosing.