How do you say does anyone in the office speak English in Spanish?

It depends on the question being asked.

If you are asking is somebody is present when you are unable to see a person (such as in a dark area or over the phone) the following two questions are applicable.

¿Quién está?

¿Hay alguien?

If you are pointing at a map or a specific location and are saying "anyone there" as a shorthand for "does anyone live there" or "is anyone in there normally", the Spanish would be: ¿Hay alguien allá?