Serra High School in San Mateo, CA
- Barry Bonds, Class of 1982, Major League Baseball left fielder (1986-) for the San Francisco Giants
- Tom Brady, Class of 1995, NFL quarterback for the New England Patriots(2000-), three-time Super Bowl champion, two-time Super Bowl MVP, 2007 NFL MVP
- Jim Fregosi, Class of 1959, Major League Baseball shortstop (1961-1971) and manager, 6-time All-Star, Gold Glove Award winner
- Jesse Freitas, Class of 1969, NFL quarterback for the San Diego Chargers(1974-1975)
- Gregg Jefferies, Class of 1985, Major League Baseball infielder (1987-2000), 2-time All-Star
- Joe Kmak, Class of 1981, Major League Baseball catcher (1993,1995) for the Milwaukee Brewers and Chicago Cubs(and currently a Math Teacher at Serra High School)
- Chuck Lofgren, Class of 2004, drafted by the Cleveland Indians, 2006 Player of the Year Kinston Indians
- John Robinson, Class of 1954, NFL Coach (1975, 1983-1991), College Football Coach (1960-1974, 1976-1982, 1993-1997, 1999-2004)
- Tom Scott, Class of 1969, CFL Hall of Fame member
- Dan Serafini, Class of 1992 Major League Baseball pitcher (1996-2003), Japanese Baseball League
- Lynn Swann, Class of 1970, former NFL wide receiver for the Pittsburgh Steelers (1974-1982), Hall of Famer, Super Bowl MVP
Source: Wikipedia
I thought Long Beach Polytechnic, Long Beach, CA had produced the most professional athletics at least 26 that I am aware of.
