Frostbite can occur if a cold pack made from ammonium nitrate is applied directly to the skin for an extended period. Ammonium nitrate, when dissolved in water, absorbs heat and can create a very low temperature, potentially leading to tissue damage similar to frostbite. To prevent frostbite, it's essential to use a barrier, such as a cloth, between the cold pack and the skin and to limit exposure time.
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