How can one enhance the pain killing effects of hydrocodone?

The best suggestion would be to either have your doctor up your dose, or switch to a more potent painkiller. Oxycodone (OxyContin), oxymorphone (Opana), and morphine (MS Contin) are much more potent than hydrocodone, but also more dangerous. However, if you did switch you would be at an extremely low risk of any healt issues related to the painkillers as long as you take them as prescribed. Most people are prescribed the more potent painkillers twice a day, but as long as you do not exceed 4 times a day your body will be fine. Opana is the strongest painkiller on the market, so it's highly unlikely you'd need to exceed taking it twice a day as prescribed.