Lifecycle of canine parvovirus

Briefly:

1. Cells are exposed to parvovirus and take it up.

2. Some trigger causes parvovirus to release its genetic material.

3. Host cells begin to replicate the parvovirus; parvovirus is 100% dependent on its host for replication machinery.

4. Viral particles are released.

Specifically:

Canine parvovirus is a small non-encapsulated single-stranded DNA virus related to feline panleukopenia virus. It binds to the canine (and in some cases feline) transferrin receptor. It is probably taken up through clathrin-mediated endocytosis according to Parrish et al in J Virol 2004 Jul;78(13):6709-14. An as-yet unknown trigger causes the release of its ssDNA. The DNA then uses host ribosomes to synthesize its VP1 and VP2 (capsid) proteins as well as its NS1 and NS2 (for non-structural) proteins. Host DNA-dependent DNA polymerase replicates the genome. Packaging occurs, probably helped along by the non-structural proteins, followed by heavy-capsid release (heavy capsid means capside with DNA inside).

For binding, see http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17420467

For uptake see http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15194745

Basically a PubMed search of Parrish CR[Author] will give you all the best articles on CPV-2 as it's called.