How much gas will it take to get from Louisville Kentucky to Birmingham Alabama?

The distance from Louisville, Kentucky, to Birmingham, Alabama, is approximately 340 miles. The amount of gas required will depend on your vehicle's fuel efficiency; for example, if your car averages 25 miles per gallon, you would need about 14 gallons of gas for the trip. Fuel prices can vary, so it's a good idea to check current gas prices for a more accurate cost estimation.