Can you get a job that requires security clearance with a DUI on your record?

It is possible that you could get a security clearance with a DUI. They are mostly looking to see if you are trustworthy, but they also look to see what it would take for someone to leverage you for information, like if you were having an affair, owed a bunch of money, etc.

I'd be surprised if you got the job, mostly because driving is probably a core requirement of any job with a security clearance.