Yes, you can use a 225/60R16 tire on a 2001 Ford Expedition, but it's important to note that this size may not be optimal for the vehicle. The standard tire size for the Expedition is typically larger, such as 265/70R16 or 275/60R17, depending on the specific model and trim. Using a smaller tire could affect handling, ride quality, and speedometer accuracy. Always consult your owner's manual or a tire professional for the best fit and safety recommendations.
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