The movie? no well...unless someone threw it at you.
However I assume you mean a poltergeist and no they cant. In the same sense that a pixie can't hurt you. There is no peer review evidence that ghosts exist in any form and as a rule something that does not exist cannot hurt you.
However since your asking this question I can safely assume you believe ghosts exist, in which case, if ghosts do in fact exist, there has yet to be a documented case of one ever injuring a human.
This means one of three things
1. Ghosts do not exist.
2. Ghosts exist but cannot harm you.
3. Ghosts exist and can harm you but never do.
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