Is it safe to take a flexeril after taking a oxycodone 6 hours before?

Yep.

That combination is actually very commonly prescribed for severe neck pain caused by an accident or disk herniation resulting in bad muscle spasms. I guarantee if you STOP taking the Flexeril, you'll find out how much good it's doing after it wears off in about 48 hours.

Make sure you stick to the dosages indicated on your prescriptions. Even though I use high amounts of opiates (Fentanyl and Percocet) Flexeril is the only drug that can actually knock me out anymore. Fantastic drug for muscle spasms.

Since it's a muscle relaxer, if you're more susceptible to the depressant side effects of the Oxycodone the combination can make you pretty drowsy, so caution is needed if you're not used to taking a lot.

It's been a while since I had to use Flexeril (about 2 years ago after my 3rd spinal operation) but my biggest recollection is after my first surgery on my cervical spine I was using it for about 6 weeks and ran out when I went to California to recuperate. I didn't realize how much it was keeping the spasms down until I ran out. Keep taking it per your prescribed schedule.