How many miles does it take to get to Michigan from Indianapolis?

Without knowing where in the two parts of Michigan (North of Wisconsin and North of Indiana) you are starting from, it is not possible to give an exact answer your question. According to google Maps; it's about 350 miles, or 6 1/2 hours driving time, from the middle of the state that above Indiana. It could be a lot more, or a lot less, depending on what part of the state of Michigan is your starting point. It is a big state and in two separate parts.