Vicodin detection time

3-7 days I have taken my prescribed vicodin 2 days prior to testing and came up negative. It really depends on the strength and how often you take it. In addition, the amount of fluids you drink directly affect the time that any opioid stays in your system. The more you drink water, the faster it's out of your system. This information comes from my personal experience and the advice from 2 RNs that I personally know.