Does a balloon filled with heleum depend on gravity?

I am not sure what you mean by 'depend' (please try and make your questions clear) but if you mean does the fact that a helium filled balloon will float (or rise) depend on gravity? Then the answer is Yes. if you were to take a helium filled balloon to the space station and release it inside, it would not rise, it would behave just the same as if you released a bunch of keys.