What two enzymes produce prostaglandins?

Prostaglandins are primarily produced by two key enzymes: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 is typically expressed in many tissues and is involved in the maintenance of normal physiological functions, while COX-2 is induced during inflammatory responses and is associated with pain and inflammation. Both enzymes convert arachidonic acid, a fatty acid released from cell membrane phospholipids, into prostaglandin H2, the precursor for various prostaglandins.