Which groups did Nazis single out for particularly cruel treatment?

Nazis singled out several groups for particularly cruel treatment, most notably Jews, who were targeted for systematic extermination during the Holocaust. Other groups included Romani people, disabled individuals, homosexuals, political dissidents, and Jehovah's Witnesses, all of whom faced severe persecution, imprisonment, and often death. The regime's ideology portrayed these groups as threats to the Aryan race and German society, justifying their brutal treatment under a framework of racial purity and nationalism.