What events led to the end of the Inca Empire?

The end of the Inca Empire was largely due to the Spanish conquest led by Francisco Pizarro in the early 1530s. Key factors included the internal strife caused by a civil war between rival brothers Atahualpa and Huáscar, which weakened the empire. Additionally, the introduction of European diseases, such as smallpox, devastated the Inca population, further diminishing their ability to resist conquest. Ultimately, the combination of military defeat and social disruption led to the fall of the Inca Empire.