Is simponi effective without methotrexate

In the U.S., Simponi is approved as a 50 mg subcutaneous injection once a month and is indicated
In combination with methotrexate for the treatment of adult patients with moderately to severely active rheumatoid arthritis
Alone or in combination with methotrexate for the treatment of adult patients with active psoriatic Arthritis
For the treatment of adult patients with active ankylosing spondylitis
Simponi is available in two dosage forms. The Simponi SmartJect is a novel autoinjector designed to meet the needs of arthritis patients that has received the Ease-of-Use Commendation by the Arthritis Foundation. Simponi is also available as an easy to use prefilled syringe.