Vinegar and Baking Soda can be mixed, and when they are a chemical reaction is observed (it bubbles and foams quite a bit).
Vinegar is dilute acetic acid (CH3COOH) while Baking Soda is Sodium Bicarbonate (NaHCO3). An acid and a base. Mixing the two results in the following reaction:
CH3COOH + NaHCO3 --> Na+CH3COO- + H2O + CO2
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