Can you take Zoloft with unisom?

Zoloft (sertraline) is an antidepressant, while Unisom (diphenhydramine or doxylamine) is an over-the-counter sleep aid. Generally, there are no direct interactions between Zoloft and Unisom, but combining them can increase the risk of side effects like drowsiness and dizziness. It's important to consult your healthcare provider before taking these medications together to ensure safety and appropriateness for your specific situation.