Why do anti-cancer chemotherapy agents interfere with microtubules?

Anti-cancer chemotherapy agents often target microtubules because they are essential for cell division. Microtubules form the mitotic spindle, which is crucial for chromosome alignment and separation during mitosis. By disrupting microtubule dynamics, these agents can prevent cancer cells from successfully completing cell division, leading to cell death or apoptosis. This mechanism helps to inhibit tumor growth and proliferation.