How did Griffith experiments prove DNA is responsible for mice developing pneumonia?

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2026-07-19 15:40

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Griffith's experiments involved injecting mice with different strains of Streptococcus pneumoniae. He observed that mice injected with the heat-killed virulent strain survived, while those injected with live non-virulent strains did not. Remarkably, when he mixed heat-killed virulent bacteria with live non-virulent bacteria, the mice developed pneumonia and died. This indicated that some "transforming principle" from the dead virulent bacteria was taken up by the live non-virulent bacteria, suggesting that DNA was responsible for the trait of virulence.

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