For many dogs, it is in their nature to kill a small animal such as guinea pig.
A well trained dog will not hurt a guinea pig, particularly if it is a breed meant for herding rather than hunting, such as a border collie.
It is unwise, however, to leave the two together unsupervised - just in case.
House your guinea pig in a cage with a top and a closed open and closed area so the dog can not get in to the cage and hurt your guinea pig.
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