What is the best route to take to get from vero bh fl to naples?

To get from Vero Beach, FL, to Naples, FL, the best route is to take I-95 South to I-595 West, then merge onto I-75 South (Alligator Alley). Stay on I-75 South until you reach the Naples exit. This route is approximately 120 miles and typically takes about 2 hours, depending on traffic conditions.