Is sickle cell passed on from mom or dad?

Sickle cell disease is inherited in an autosomal recessive pattern, meaning a child must receive a copy of the sickle cell gene from both parents to have the disease. If both parents carry the sickle cell trait (one normal and one sickle cell gene), there is a 25% chance with each pregnancy that their child will inherit the disease. Therefore, sickle cell can be passed on from either the mother or the father, or both.