How can I effectively use baking soda in a drain to unclog it?

To effectively use baking soda in a drain to unclog it, pour about 1 cup of baking soda down the drain followed by 1 cup of vinegar. Let it sit for about 30 minutes, then flush the drain with hot water. The fizzing action of the baking soda and vinegar can help break down clogs and clear the drain.