What is the difference between genetic disorders and polygenic disease?

Genetic disorders are caused by mutations in a single gene or chromosomal abnormalities, which typically lead to specific, identifiable conditions, such as cystic fibrosis or sickle cell anemia. In contrast, polygenic diseases result from the combined effect of multiple genes, often influenced by environmental factors, and include conditions like diabetes and Heart disease. While genetic disorders are generally inherited in a clear pattern, polygenic diseases involve complex interactions and risk factors that make their inheritance less predictable.