Beta-endorphin is produced from the pro-hormone proopiomelanocortin (POMC). POMC is a precursor that also gives rise to other important peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormones (MSH). The cleavage of POMC in the pituitary gland and other tissues leads to the formation of these various bioactive peptides, including beta-endorphin, which plays a role in pain relief and the regulation of mood.
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