If you take depakote ER 1000mg every day and then miss a dose can that cause a seizure?

Yes, missing a dose of Depakote ER (divalproex sodium) can increase the risk of a seizure, especially if you have epilepsy or a history of seizures. Consistent levels of the medication in your system are important for its effectiveness in preventing seizures. If you miss a dose, it's advisable to take it as soon as you remember, unless it's close to the time for your next dose. Always consult your healthcare provider for specific guidance.