How does the black plague affect the homeostasis of skin cells?

The Black Plague, caused by the bacterium Yersinia pestis, can severely disrupt the homeostasis of skin cells through its systemic effects on the body. The infection leads to inflammation, immune response activation, and the formation of buboes, which can compromise blood flow and oxygen supply to the skin. This disruption can result in necrosis, skin lesions, and other dermatological manifestations, ultimately affecting the integrity and function of skin cells. Additionally, the high fevers associated with the plague can lead to dehydration and further stress on skin cell homeostasis.