Take the Downtown 4 or 5 express trains (of the 4-5-6, the dark green line), 2 stops, from 42nd Street-Grand Central Station to Brooklyn Bridge-City Hall.
You'll exit the subway at the corner of Chambers and Centre Streets, at the northeast corner of City Hall Park. Walk 3 blocks west on Chambers Street (across the park) to Church Street. Turn left onto Church Street, and walk 3 1/2 blocks south on Church Street to 100 Church Street, between Park Place and Barclay Street.
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