Without punctuation the sentence above makes no sense.
Si (no accent/tilde over the I) means "If"
Sí (with accent/tilder over the I) means "Yes"
Tu (no accent/tilde over the U) means "Your"
Tú (with accent/tilde over the U) means "You"
Assuming the comment above is supposed to read:
"Sí y no. Tú eres simpatica" means "Yes and no. You're nice"
"Sí y no tú. Eses simpatica" means "Yes and not you. You're nice"
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