Can Valium and Zolpidem be taken together?

Only if your doctor recommends that they be taken together. Otherwise, taking these two medications concomitantly may produce excessive CNS depression. Zolpidem is a nonbenzodiazepine of the imidazopyridine class, but its effects may be mediated by the neurotransmitter gamma-aminobutyric acid (GABA). Because it shares this mode of action with the benzodiazepine temazepam, there is a high risk for exaggerated CNS side effects including dizziness, confusion, light-headedness, headache, etc. and CNS depression, which may be life threatening.