Can too much diphenhydramine cause jaundice?

Yes, excessive use of diphenhydramine can potentially lead to liver damage, which may result in jaundice. Jaundice is characterized by a yellowing of the skin and eyes, typically due to liver dysfunction. While diphenhydramine is generally safe when used as directed, high doses or prolonged use can have harmful effects on the liver. If jaundice or other serious symptoms occur, it's important to seek medical attention immediately.