Do genetically modified organisms make it easier to grow food?

It is known that weeds have become resistant to glyphosate, the active ingredient in Round-up. It is also possible that insects are becoming resistant to the Bt varieties of GMO crops, and that non-targeted insects may also be affected. It is also known that GMO crops have cross pollinated with non-GMO and organic crops. There are other questions that simply have not yet been answered and may not be known yet.