Is Worcester Ma the second largest us city not on a major waterway?

Yes, Worcester, Massachusetts, is often cited as one of the largest U.S. cities not located on a major waterway. It is the second-largest city in Massachusetts and the second-largest city in the U.S. without direct access to a significant river or lake, following the city of El Paso, Texas. Worcester's location and urban development have not been significantly influenced by proximity to major bodies of water.